Paratose
WebParatose, abequose, tyvelose, and ascarylose are characteristic constituents of the lipopolysaccharides of P. pseudotuberculosis being found in Types I (or III), II, IV and V respectively. An extract of each of these types catalyzed the biosynthesis of only the CDP3,6-dideoxyhexose found in that type (with the exception of Type IV, see below). ... WebCDP-paratose synthase (EC 1.1.1.342, rfbS (gene)) is an enzyme with systematic name CDP-alpha-D-paratose:NADP + 4-oxidoreductase. This enzyme catalyses the following …
Paratose
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WebCDP- d-tyvelose 2-epimerase is responsible for the conversion of the 3,6-dideoxy sugar paratose (178) into tyvelose ( 179) via epimerization at the C (2)-position ( Scheme 35) … WebThe reversible diphosphopyridine nucleotide-dependent 2-epimerization of cytidine diphosphate 3,6-dideoxy-d-glucose (CDP-paratose) and CDP-3,6-dideoxy-d-mannose (CDP-tyvelose) is described, both in a Group D Salmonella (Salmonella enteritidis) and in Pasteurella pseudotuberculosis, Type IV.Tyvelose is, thus, the only 3,6-dideoxyhexose …
WebFeb 3, 2011 · We report the de novo asymmetric synthesis of the 3,6-dideoxy sugars abequose, paratose, and tyvelose from 2-acetylfuran. Conversion of this readily available ketone to a pyranone derivative was ... WebJan 3, 2010 · CDP-paratose epimerase. CDP-tyvelose 2-epimerase. cytidine diphosphate paratose-2-epimerase. cytidine diphosphoabequose epimerase. cytidine diphosphodideoxyglucose epimerase. cytidine diphosphoparatose epimerase. Reaction catalysed; CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose: Comment(s)
Webparatose is an intermediate in the synthesis of CDP-tyvelose. We have found that extracts of Salmonella typhi produce CDP- paratose as well as CDP-tyvelose, indicating that this nucleotide is also an intermediate in the synthesis of tyvelose in this or- ganism. The protein fraction catalyzing the conversion of CDP-n-glu- ... WebJan 3, 2010 · Details Name CDP-paratose 2-epimerase Synonyms. 5.1.3.10; CDP-tyvelose 2-epimerase; Gene Name rfbE Organism Salmonella typhi Amino acid sequence …
WebThe de novo asymmetric synthesis of the 3,6-dideoxy sugars abequose, paratose, and tyvelose from 2-acetylfuran is reported, which could be reduced and converted to either fully deprotected monosaccharides or to immediate precursors of glycosyl donors.
scottish architecture styleWebDefinition from Wiktionary, the free dictionary. Jump to navigation Jump to search. English [] Noun []. paratose (uncountable) (biochemistry) The deoxy sugar 3,6-dideoxy-D-ribo-hexose pre req for med schoolWebApr 7, 1998 · Expression and purification of CDP-paratose synthase have allowed us to fully characterize the catalytic properties of this enzyme, which is a homodimeric protein with a preference for NADPH over NADH. It catalyzes the stereospecific hydride transfer of the … pre req courses for masters in marine biologyWebNature - Contribution of Deoxymethylpentoses to the Serological Specificity of Some Bacterial Polysaccharides, and the Recognition of a New Sugar, Paratose scottish arms brunchWebJan 1, 1989 · Methyl paratose with deuterium incorporated at the C-3 axial position (3R) has been previously synthesized by going through a 2,3,4,6-tetra-O-(p-tolylsulfonyl)-a-D-gluco- side intermediate5 using a procedure which results in an additional deuterium incorporation at C-6. However, the yield from this reaction is very low (16%) and synthesis of ... prereqs vcredist12WebTyvelose epimerase catalyzes the last step in the biosynthesis of tyvelose by converting CDP-d-paratose to CDP-d-tyvelose. This unusual 3,6-dideoxyhexose occurs in the O-antigens of some types of Gram-negative bacteria. Here we describe the cloning, protein purification, and high-resolution x-ray crystallographic analysis of tyvelose epimerase … scottish architectsWebAccepted Name; CDP-paratose synthase Reaction catalysed; CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH: Comment(s) The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. scottish arms happy hour