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Trichoplein

WebAutophagy is an evolutionarily conserved and tightly regulated process that plays an important role in maintaining cellular homeostasis. It involves regulation of various genes that function to degrade unnecessary or dysfunctional cellular components, and to recycle metabolic substrates. Autophagy is modulated by many factors, such as nutritional … WebApr 1, 2012 · Trichoplein shows a low degree of sequence similarity to trichohyalin, plectin, and myosin heavy chain, and colocalizes with CK8/18 filaments in HeLa cells . Trichoplein may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells . Albatross ...

Trichoplein and Aurora A block aberrant primary cilia assembly in ...

WebSep 1, 2024 · Trichoplein (TCHP) is a protein that impinges on the stability of axonemal microtubules and acts as a negative regulator of cilia assembly [70]. Upon binding of … Webtrichoplein (G-2): sc-515025 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com BACKGROUND Trichoplein, also known as THCP (trichoplein keratin filament-binding protein) or mitostatin (mitochondrial protein with oncostatic activity), is a 498 amino christmas gift ideas for mom cheap https://pkokdesigns.com

Trichoplein controls microtubule anchoring at the …

WebAug 25, 2024 · We have shown that trichoplein (TCHP), a centriolar protein originally identified as a keratin-binding protein, is a key activator of aurora A kinase (AURKA) at centrioles and that knockdown (KD) of TCHP causes elongation of primary cilia in human retinal pigmental epithelium cells by suppressing the inhibitory effect of AURKA in … WebDec 29, 2015 · Effects of trichoplein depletion on cell cycle regulators. Proliferating RPE1 cells were transfected with siRNA for control or trichoplein (#1 and #2), and then cultured for 72 h. The cell extracts were subjected to immunoblotting analysis with p27 Kip1, p53, p21 Cip1, p16 INK4a, trichoplein, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). WebRecent investigations are focused on mitotic DNA damage response (DDR) and chromosome mis-segregations with the aim of developing more efficient anti-cancer therapies. We previously demonstrated that trichoplein keratin filament binding protein (TpMs) exhibits hallmarks of a tumor suppressor gene in cancer-derived cells and human … christmas gift ideas for mechanic

trichoplein Antibody SCBT - Santa Cruz Biotechnology

Category:Anti-trichoplein Antibody (G-2) SCBT - Santa Cruz Biotechnology

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Trichoplein

Mechanisms of ciliogenesis suppression in dividing cells

Webケラチン結合蛋白質Trichopleinの中心体における機能解析(Trichoplein, a keratin binding protein, is a functional component of centrosomes) 大室 有紀[松山], 鄒 鵬, 猪子 誠人, 衣斐 美歩, 米村 重信, 林 裕子, 森 大輔, 広常 真治, 田村 淳, 月田 早智子, 稲垣 昌樹 WebTrichoplein disappears from the basal body in quiescent cells. (A) RPE1 cells were stained with antitrichoplein (Tricho.), anti-Odf2, and anti–Centrin 2. Bottom micrograph is shown …

Trichoplein

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Webcancers Article Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells Angela Lauriola 1,2, Andrea Martello 3,4, Sebastian Fantini 5, Gaetano Marverti 1, Tommaso Zanocco-Marani 5, Pierpaola Davalli 1, Daniele Guardavaccaro 2, Sabine Mai 6, Andrea Caporali 3,* and Domenico … WebApr 30, 2012 · Trichoplein or Aurora A knockdown failed to induce ciliogenesis or cell cycle arrest in HeLa cells, which, like many cancerous cell types, have a reduced tendency to form primary cilia. “We're now investigating whether Aurora A knockdown has different effects in various normal and cancer cell lines,” says Inagaki.

WebMar 15, 2011 · Trichoplein – a widely expressed keratin intermediate filament scaffold protein – is shown by Masaki Inagaki and co-workers on page 857 to have a key role in … WebTrichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Authors - Andrea Martello. View Article. human: WB,IF: J Biol Chem. DAZ interacting protein 1 (Dzip1) phosphorylation by Polo-like kinase 1 (Plk1) regulates the centriolar satellites localization of the BBSome during the cell cycle.

WebJul 3, 2024 · Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links … WebApr 30, 2012 · Trichoplein or AurA knockdown also induced G0/G1 arrest, but this phenotype was reversed when cilia formation was prevented by simultaneous knockdown of IFT-20. These data suggest that the trichoplein–AurA pathway is required for G1 progression through a key role in the continuous suppression of primary cilia assembly.

WebGeneral description. Trichoplein (TCHP) is also termed as mitostatin (TpMs). It is a keratin binding protein, which is partly located in the mitochondria. This gene is located on …

WebMar 1, 2005 · Keratins 8 and 18 (K8/18) are major components of the intermediate filaments (IFs) of simple epithelia. We report here the identification of a novel protein termed … gervais emergency consultingWebNdel1, a protein located at the subdistal appendage of mother centriole, functions as an upstream regulator of the trichoplein–Aurora A pathway that suppresses ciliogenesis in proliferating cells. (PDF) Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway Tohru Kiyono - Academia.edu gervais electric nashvillegervais electric westford maWebSep 26, 2016 · Instead, trichoplein depletion results in the elevation of p27 , one of CKIs (Fig. 2). P27 is known to increase during quiescent state but decrease during proliferation state [ 82 , 83 ]. Since CDK activities are also critical for the G0/G1 transition through the phosphorylation of pRb (the product of the retinoblastoma tumor suppressor gene) [ 89 – … gervais electric franklin tnWebEMBO Press gervais electric ottawaWebBritish Heart Foundation - Search results christmas gift ideas for mom from kidsWebJun 14, 2024 · KCTD17 has also been reported to function as an adaptor of the cullin-3 ubiquitin ligase to mediate ubiquitination and degradation of trichoplein, which is a negative regulator of ciliogenesis. 32 Both neurons and astrocytes contain a primary cilium, and ciliogenesis has been reported to play an important role in brain development. 84 This ... gervais electrical