WebAutophagy is an evolutionarily conserved and tightly regulated process that plays an important role in maintaining cellular homeostasis. It involves regulation of various genes that function to degrade unnecessary or dysfunctional cellular components, and to recycle metabolic substrates. Autophagy is modulated by many factors, such as nutritional … WebApr 1, 2012 · Trichoplein shows a low degree of sequence similarity to trichohyalin, plectin, and myosin heavy chain, and colocalizes with CK8/18 filaments in HeLa cells . Trichoplein may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells . Albatross ...
Trichoplein and Aurora A block aberrant primary cilia assembly in ...
WebSep 1, 2024 · Trichoplein (TCHP) is a protein that impinges on the stability of axonemal microtubules and acts as a negative regulator of cilia assembly [70]. Upon binding of … Webtrichoplein (G-2): sc-515025 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com BACKGROUND Trichoplein, also known as THCP (trichoplein keratin filament-binding protein) or mitostatin (mitochondrial protein with oncostatic activity), is a 498 amino christmas gift ideas for mom cheap
Trichoplein controls microtubule anchoring at the …
WebAug 25, 2024 · We have shown that trichoplein (TCHP), a centriolar protein originally identified as a keratin-binding protein, is a key activator of aurora A kinase (AURKA) at centrioles and that knockdown (KD) of TCHP causes elongation of primary cilia in human retinal pigmental epithelium cells by suppressing the inhibitory effect of AURKA in … WebDec 29, 2015 · Effects of trichoplein depletion on cell cycle regulators. Proliferating RPE1 cells were transfected with siRNA for control or trichoplein (#1 and #2), and then cultured for 72 h. The cell extracts were subjected to immunoblotting analysis with p27 Kip1, p53, p21 Cip1, p16 INK4a, trichoplein, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). WebRecent investigations are focused on mitotic DNA damage response (DDR) and chromosome mis-segregations with the aim of developing more efficient anti-cancer therapies. We previously demonstrated that trichoplein keratin filament binding protein (TpMs) exhibits hallmarks of a tumor suppressor gene in cancer-derived cells and human … christmas gift ideas for mechanic